Examples:
Detailed statistics (number of interactions in each layer)
| Species |  Caenorhabditis elegans |  Drosophila melanogaster |  Danio rerio |  Homo sapiens |
| Pathway interactions | 184 | 151 | 216 | 20,867 |
| Pathway regulations | 0 | 0 | 0 | 3,040 |
| Post-translational modifications | 0 | 0 | 0 | 31,784 |
| Further interactions | 732 | 2,647 | 10 | 356,599 |
| Transcriptional regulators | 8 | 382 | 0 | 167,468 |
| Post-transcriptional regulators (miRNA) | 75 | 67 | 41 | 171,433 |
| lncRNA regulators | 0 | 0 | 0 | 1,307 |
Features
SignaLink is an integrated resource to analyze signaling pathway cross-talks, transcription factors, miRNAs and regulatory enzymes. Main features:
- A signaling network resource with known and predicted information for human and model organisms
- Manually curated dataset of major signaling pathways - including curated data from resources such as ACSN, InnateDB, Reactome and Signor
- Extends pathways with integrated regulatory resources to contain pathway-specific transcription factors, miRNA, scaffolds and post translational modifying enzymes
- Proteins are classified by pathway position (core/non-core) and function (ligand, receptor, mediator, etc.)
- Signaling interactions are directed and labeled with PubMed IDs of the publications of experimental evidence
- A multi-layered network structure allows the selection of user-specific details
- Allows filtering based on tissue or sub-cellular localization
- Supporting downloads in csv or psimi tab formats
With SignaLink You can
- Browse signaling pathways, cross-talks and multi-pathway proteins
- Select transcriptional, post- transcriptional and post translational regulators of a signaling pathway
- Download species- and pathway-specific information in several formats
- Design genetic/biochemical experiments to verify predicted pathway member proteins
- Model tissue- or disease-specific signaling processes by merging SignaLink with expression data
- Discover novel signaling drug target candidates
ChangeLog
StatisticsMore details
| Species | Caenorhabditis elegans | Drosophila melanogaster | Danio rerio | Homo sapiens |
| Proteins | 537 | 1,426 | 185 | 17,949 |
| miRNAs | 57 | 30 | 2 | 1,987 |
| Interactions | 999 | 3,247 | 267 | 752,498 |
| Pathways | RTK, WNT/Wingless, Hedgehog, TGF, NHR, Notch, HIPPO, TNF, JAK/STAT, BCR, TCR, TLR, Innate Immune Pathways |
How to cite SignaLink
SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks. Csabai L*, Fazekas D*, Kadlecsik T*, Szalay-Bekő M, Bohár B, Madgwick M, Módos D, Ölbei M, Gul L, Sudhakar P, Kubisch J, Oyeyemi O J, Liska O, Ari E, Hotzi B, Billes V A, Molnár E, Földvári-Nagy L, Csályi K, Demeter A, Pápai N, Koltai M, Varga M, Lenti K, Farkas I J, Türei D, Csermely P, Vellai T, Korcsmáros T (* equal contributions) Nucleic Acids Research, Volume 50, Issue D1, 7 January 2022, Pages D701–D709
SignaLink 2.0 - A signaling pathway resource with multi-layered regulatory networks. Fazekas D*, Koltai M*, Türei D*, Módos D, Pálfy M, Dúl Z, Zsákai L, Szalay-Bekő M, Lenti K, Farkas I J, Vellai T, Csermely P, Korcsmáros T (* equal contributions)
Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery. Korcsmáros T*, Farkas I J*, Szalay-Bekő M, Rovó P, Fazekas D, Spiro Z, Böde C, Lenti K, Vellai T, Csermely P (* equal contributions)
The old SignaLink 2.0 website is temporary unavailable. The old database is still available on the Download page.